BOPI 08 BR/2024 REPERTOIRE NUMERIQUE 16 (72) DRUMMOND, Daryl C. (US); KOSHKARYEV, Alexander (US); KIRPOTIN, Dmitri B. (US); HAYES, Mark E. (US) et FULTON, Ross B. (US) (73) AKAGERA MEDICINES, INC., 5 Essex Street, BOXFORD, Massachusetts 01921 (US) (74) Cabinet Spoor & Fisher Inc. Ngwafor & Partners, The House of Gideon, Golf/Bastos Quater, Opposite The American Embassy, Entrance-Saint John Paul II Boulevard, P.O. Box 8211, YAOUNDE (CM). (57) The present disclosure provides for improved compositions of ionizable lipid nanoparticles for the 10 delivery of therapeutic nucleic acids to cells. Cationic ionizable lipids are engineered with improved stability to oxidative degradation while in storage, while retaining high transfection activity or potency in cells. These lipids are designed to be biodegradable, thus improving the tolerability of nanoparticles formed with them in vivo. In addition, targeting of these nanoparticles in a highly specific manner to dendritic cells is provided for through inclusion of antibody conjugates directed against cell surface 15 receptors. (11) 21604 Consulter le mémoire (51) E21B 19/22 (2018.01); E21B 33/076 (2018.01) (21) 1202300222 - PCT/IB2020/001106 (22) 17/12/2020 (54) A subsea well intervention system and method. (72) CAMUS, Mathieu (FR) (73) TOTALENERGIES ONETECH, La Défense 6, 2 Place Jean Millier, 92400 COURBEVOIE (FR) (74) Cabinet Spoor & Fisher Inc. Ngwafor & Partners, The House of Gideon, Golf/Bastos Quater, Opposite The American Embassy, Entrance-Saint John Paul II Boulevard, P.O. Box 8211, YAOUNDE (CM). (57) A subsea well intervention system for inserting tubing (104) from a floating vessel (100) into a subsea well (200), the floating vessel not comprising a derrick, the system comprising a subsea tree (201) installed upon the well, a blowout preventer module (202) connected onto the subsea tree, a lubricator module (203) connected onto the blowout preventer module, a tubing (104) extending from the floating vessel down to the well and through the lubricator module, the blowout preventer module and the subsea tree. The lubricator module (203) includes a pushing device (500) inside a cavity of said lubricator device, the pushing device being adapted to force the tubing to move down inside the well.
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