BOPI 06 BR / 2025 REPERTOIRE NUMERIQUE 20 (30) US n° 63/213,900 du 23/06/2021; US n° 63/239,671 du 01/09/2021; US n° 63/239,847 du 01/09/2021; US n° 63/290,892 du 17/12/2021; US n° 63/290,960 du 17/12/2021; US n° 63/298,565 du 11/01/2022; US n° 63/305,071 du 31/01/2022; US n° 63/268,577 du 25/02/2022; US n° 63/314,369 du 26/02/2022; US n° 63/316,634 du 04/03/2022; US n° 63/317,856 du 08/03/2022; US n° 63/362,295 du 31/03/2022; US n° 63/326,201 du 31/03/2022; US n° 63/327,179 du 04/04/2022 et US n° 63/339,250 du 06/05/2022 (54) Antisense compounds and methods for targeting CUG repeats. (72) DURRANT-WHYTE, Hugh (AU); SHEN, Xiulong (US); GILLESPIE, Alistair (CA) et QIAN, Ziqing (US) (73) ENTRADA THERAPEUTICS, INC., 6 Tide Street, BOSTON, Massachusetts 02210 (US) (74) SPOOR & FISHER Inc. NGWAFOR & PARTNERS SARL, The House of Gideon, Golf/Bastos Quarters, Opposite The American Embassy, Entrance-Saint John Paul II Boulevard, B.P. 8211, YAOUNDE (CM). (57) Compounds comprising a cyclic peptide, such as a cyclic cell penetrating peptide, and an antisense compound are provided. The antisense compound binds to a gene having an expanded CTG repeat or a gene transcript having an expanded CUG repeat. The compounds can be delivered to subjects to treat diseases associated with expanded CTG-CUG repeats, such as myotonic dystrophy type 1 (DM1), spinocerebellar ataxia-8 (SCA8), and Huntington disease like-2 (HDL2). ________________________________________ (11) 21932 Consulter le mémoire (51) C03C 3/066 (2023.01); C03C 3/068 (2023.01); C03C 3/093 (2023.01); C03C 3/095 (2023.01); C03C 4/08 (2023.01) (21) 1202400055 - PCT/IB2022/061710 (22) 02/12/2022 (54) Radiation shielding glass having zincbarium-borosilicate composition. (72) KURTULUS, Recep (TR) et KAVAS, Tarier (TR) (73) GUROK HOLDING B.V., Keizersgracht 555, ruimte 4.03 1017 DR, AMSTERDAM (NL) (74) S.C.P AKKUM, AKKUM & Associates, No. 1777, rue 6.261, Yaoundé 2, Auditorium Jean Paul II boulevard, Face Brigade de Gendarmerie, Mbankolo, B.P 4966, YAOUNDE (CM). (57) The invention relates to a radiation shielding zincbarium-borosilicate glass material produced from easily accessible, low-cost and abundantly available starting raw materials, particularly for Xrays and / or gamma rays and / or fast neutrons and / or the like, by means of uniquely designed glass compositions, In particular the use of sodium oxide (Na2O), silicon dioxide (SiO2), boron
RkJQdWJsaXNoZXIy MTM1NDc3MA==