BOPI 06 BR / 2025 REPERTOIRE NUMERIQUE 27 360 single doses of the composition to be implemented according to the present invention. Fig. 1 ________________________________________ (11) 21942 Consulter le mémoire (51) A61K 39/00 (2023.01); A61K 39/09 (2023.01) (21) 1202400360 (22) 25/09/2024 (30) IN n° 202323028039 du 17/04/2023 (54) Methods for improving the adsorption of polysaccharide-protein conjugates and multivalent vaccine formulation obtained thereof. (72) POONAWALLA Cyrus Soli (IN) (73) SERUM INSTITUTE OF INDIA PRIVATE LIMITED, 212/2, Off Soli Poonawalla Road, Hadapsar, PUNE 411 028, Maharashtra (IN) (74) S.C.P AKKUM, AKKUM & Associates, No. 1777, rue 6.261, Yaoundé 2, Auditorium Jean Paul II boulevard, Face Brigade de Gendarmerie, Mbankolo, B.P 4966, YAOUNDE (CM). (57) The present disclosure relates to vaccine compositions comprising pneumococcal polysaccharide-carrier protein conjugates. The present disclosure particularly relates to improved, stable, immunogenic multivalent Streptococcus pneumoniae polysaccharide-protein conjugate vaccine compositions having at least three distinct carrier proteins, preparing the vaccine compositions and methods for prevention and/or treatment of subjects with Streptococcus pneumoniae. These multivalent pneumococcal compositions will overcome carrier induced epitopic suppression, provide enhanced immune response for new serotypes (as compared to existing approved vaccines) and also help address the emergence of non-vaccine serotypes. Fig. 2
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