BOPI 08 BR/2023 REPERTOIRE NUMERIQUE 15 Fig. 11 Consulter le mémoire ________________________________________ (11) 21087 (51) A61K 31/4162 (2018.01); A61K 31/429 (2018.01); A61P 1/16 (2018.01); A61P 11/00 (2018.01); C07D 231/56 (2018.01); C07D 487/04 (2018.01); C07D 498/18 (2018.01) ; C07D 513/04 (2018.01) (21) 1202100514 - PCT/US2020/032832 (22) 14/05/2021 (30) US n° 62/847,562 du 14/05/2019; US n° 63/004,813 du 03/04/2020 (54) Condensed tricyclic pyrroles as Alpha-1 Antitrypsin modulators. (72) JONES, Peter (US); BRODNEY, Michael Aaron (US); SHI, Yi (US); SHRESTHA, Muna (US); STAVROPOULOS, Kathy (US); NUHANT, Philippe Marcel (US); MEDEK, Ales (US); BANDARAGE, Upul Keerthi (US); BLIGH, Cavan McKeon (US); BOUCHER, Diane (US); BOYD, Michael John (US); CLARK, Michael Philip (US); COTTRELL, Kevin Michael (US); DAMAGNEZ, Veronique (US); FANNING, Lev Tyler Dewey (US); FIMOGNARI, Robert Francis (US); FLEMING, Gabrielle Simone (US); GAGNON, Kevin James (US); GARCIA BARRANTES, Pedro Manuel (US); GIACOMETTI, Robert Daniel (US); GIROUX, Simon (US); GREY JR., Ronald Lee (US); GUIDO, Samantha (US); HALL, Amy Beth (US); HOOD, Sarah Carol (US); HURLEY, Dennis James (US); JOHNSON, JR., Mac Arthur (US); KESAVAN, Sarathy (US); LAI, Mei-Hsiu (US); LIU, Siying (US); LOOKER, Adam (US); MAXWELL, Brad (US); MAXWELL, John Patrick (US); OVERHOFF, Kirk Alan (US); RODAY, Setu (US); ROEPER, Stefanie (US); RONKIN, Steven M. (US); SAWANT, Rupa (US); SPOSATO, Marisa (US); SWETT, Rebecca Jane (US); TANG, Qing (US); TAPLEY, Timothy Lewis (US); THOMSON, Stephen (US) et ZAKY, Mariani (US) (73) Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, BOSTON, Massachusetts 02210 (US) (74) SPOOR & FISHER Inc. NGWAFOR & PARTNERS Sarl, The House of Gideon, Golf/Bastos Quarters, Opposite The American Embassy, Entrance-Saint John Paul II Boulevard, P.O. Box 8211, YAOUNDE (CM). (57) The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiencv (AATD), according to formula (I), tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the
RkJQdWJsaXNoZXIy MTM1NDc3MA==