BOPI 08 BR/2023 REPERTOIRE NUMERIQUE 29 Fig. 13 Consulter le mémoire ________________________________________ (11) 21105 (51) A61K 31/4162 (2018.01); A61P 25/28 (2018.01); C07D 498/16 (2018.01) ; C07D 498/18 (2018.01) (21) 1202200455 - PCT/EP2021/061827 (22) 05/05/2021 (30) EP n° 20315236.8 du 06/05/2020; EP n° 21305112.1 du 28/01/2021 (54) New macrocyclic LRRK2 kinase inhibitors. (72) LE TIRAN, Arnaud (FR); BLOM, Petra Marcella (BE); HOUSSEMAN, Christopher Gaétan (FR); DAUGAN, Alain (FR); DUMOULIN, Audrey (FR); LAUGEOIS, Maxime (FR); DENIS, Alexis (FR); FAUCHER, Nicolas (FR); BOTEZ, luliana (FR); CHRISTENSEN, Kenneth (DK) et LAMOTTE, Yann (FR) (73) LES LABORATOIRES SERVIER, 35 rue de Verdun, 92284 SURESNES (FR) et ONCODESIGN PRECISION MEDICINE (OPM), 18 Rue Jean Mazen, 21000 DIJON (FR) (74) S.C.P AKKUM, AKKUM & Associates, n° 1777, Rue 6.261, Auditorium Jean Paul II, Quartier Mbankolo, B.P. 4966, YAOUNDE (CM). (57) Compounds of formula (I): wherein R, XI, X2, X3, Zl, Z2, Z3, A and Ra are as defined in the description Medicaments. Compounds of formula (I)
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