BOPI 08 BR/2023 REPERTOIRE NUMERIQUE 30 Consulter le mémoire ________________________________________ (11) 21106 (51) B01L 3/00 (2018.01); G01N 33/543 (2018.01) ; G01N 33/569 (2018.01) (21) 1202200463 - PCT/GB2021/051071 (22) 04/05/2021 (30) GB n° 2006581.9 du 04/05/2020; GB n° 2016894.4 du 23/10/2020 (54) A diagnostic device. (72) MICO, Simon (GB) (73) BIO-DIAGNOSTICS LIMITED, Upton Industrial Estate, Rectory Road, UPTON-UPONSEVERN, Worcestershire WR8 OLX (GB) (74) Cabinet BONNY & ASSOCIÉS, LAW FIRM, B.P. 35349, YAOUNDE (CM). (57) A diagnostic device (1) for detecting a first member of a reporter-analyte pair. The diagnostic device comprises an inlet for receiving a liquid, biological sample and a porous membrane element (10) comprising a detection portion. The detection portion is in liquid communication with the inlet and a second member of the reporteranalyte pair is immobilised on the detection portion. One of the first or second member of the reporter-analyte pair comprises a biological antigen and the other of the first or second member of the reporter-analyte pair comprises an antibody specific for the biological antigen. The biological antigen comprises a spike protein, or a fragment thereof, of COVID-19. The device is for independent detection of the spike protein, or the fragment thereof, or of an antibody specific for the spike protein, or the fragment thereof, in the biological sample. Fig. 1 & Fig. 2 Consulter le mémoire ________________________________________ (11) 21107 (51) A61K 31/501 (2018.01); A61P 35/04 (2018.01); C07D 231/16 (2018.01) ; C07D 401/14 (2018.01) (21) 1202200467 - PCT/US2021/031091 (22) 06/05/2021 (30) US n° 63/022,475 du 09/05/2020; US n° 63/149,143 du 12/02/2021; US n° 63/177,378 du 20/04/2021 (54) Methods of manufacturing a bifunctional compound, ultrapure forms of the bifunctional compound, and dosage forms comprising the same.
RkJQdWJsaXNoZXIy MTM1NDc3MA==